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KMID : 0043319940170040269
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Archives of Pharmacal Research
1994 Volume.17 No. 4 p.269 ~ p.272
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Inhibitory Effect of the Root of Coptis japonica on Catecholamine Biosynthesis in PC12 Cells
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Lee Myung-Koo
Park Woo-Kyu
Kim Hack-Seang
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Abstract
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The effect of the root of Coptis japonica (COPT), both dichloromethane soluble and insoluble fractions, on catecholamine contents and tyrosine hydorxylase (TH) activity in PC12 cells was investigated. fractions showed 21 and 53% inhibitions on dopamine content, respectively, at a ocncentraction of 40 .mu.g/ml in medium : the fraction proveided a grateer inhibitory effect. The TH activity was reduced by the treatment of COPT ( fraction). These results suggest that COPT has an inhibitory effect on the catecholamine biosynthesis by the reduction of TH activity in PC12 cells.
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KEYWORD
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Coptis japonica, Catecholarmines, Tyrosine Hydroxylase, PC12 Cells
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